The major U.S. equities indexes were mixed at midday Thursday, with the Dow Jones Industrial Average down close to 400 points as UnitedHealth Group ( UNH ) shares plunged. The tech-heavy Nasdaq and the S&P 500 were slightly higher.

UnitedHealth Group ( UNH ) shares led Dow and S&P 500 decliners, after the healthcare group pared back its forecasts , citing higher costs. Its slump weighed on shares of other insurers, including Humana ( HUM ), Elevance Health ( ELV ) and CVS Health ( CVS ).

Nvidia ( NVDA ) and Advanced Micro Devices ( AMD ) slid, extending Wednesday's declines after they warned of a hit from new export curbs to China. Broadcom ( AVGO ) shares also lost ground.

Eli Lilly ( LLY ) led S&P 500 gainers after the pharmaceutical giant released promising trial results for its oral drug pill orforglipron. Shares in rival Novo Nordisk ( NVO ) fell as BMO downgraded the Danish drug developer, citing its loss of its lead in the weight-loss drug race.

Netflix ( NFLX ) shares rose as the streamer, which is slated to report first-quarter results after markets close, is viewed by analysts as mostly shielded from tariffs and an economic downturn.

Crude oil futures and the yield on the 10-year Treasury note rose. The U.S. dollar rose against the euro and yen and lost ground against the pound. Prices for major cryptocurrencies mostly gained.

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